Pleuromutilin solvates with a halogenated aliphatic hydrocarbon - useful for purifying crude pleuromutilin antibiotic

Solvats de la pleuromutiline et procede de purification de la pleuromutiline par l'intermediaire de tels solvats

Abstract

A solvate of pleuromutilin (I) with a halogenated aliphatic hydrocarbon (II) in the molar ratio of 1:1, is new. The solvate is useful for purifying (I), thus crude (I) can be converted into its solvate and which can be converted to pure (I) by e.g., heating. (I) is known antibiotic which can be converted into other pleuromutilin derivs. In an example, a solvate is prepd. by dissolving crude (I) in 1,1,1-trichloroethane, filtering off the insoluble impurities, cooling for 24 hrs. when the solvate crystallises out.
<P>L'invention a pour objet des solvats de la pleuromutiline avec un hydrocarbure halogéné et leur procédé de préparation. </P><P>Les solvats selon l'invention sont obtenus par réaction de la pleuromutiline avec un hydrocarbure halogéné. </P><P>Ces solvats peuvent être utilisés pour la purification de la pleuromutiline brute.</P>

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Patent Citations (1)

    Publication numberPublication dateAssigneeTitle
    US-4089891-AMay 16, 1978BiochemiePleuromutilin solvates

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