5-Methoxy-psoralen for psoriasis treatment - prepd. from phloroglucinol via mono-methyl ether, 6-hydroxy-4-methoxy-coumaran-3-one and coumaran

Nouveau medicament contenant un derive du psoralene

  • Inventors:
  • Assignees: Goupil Jean Jacques
  • Publication Date: May 18, 1979
  • Publication Number: FR-2406444-A1

Abstract

<P>Nouveau médicament caractérisé en ce qu'il contient du 5-méthoxy-psoralène comme substance active. </P><P>Application : traitement du psoriasis et de diverses dermatoses.</P>
Prodn. of 5-methoxy-psoralene (I) comprises (a) methylation of phloroglucinol (II) using methanol and a current of gaseous HCl to give a mixt. of the mono- and di-methyl ethers and isolation of the monomethyl ether by fractional distn. (b) cyclisation of phloroglucinol mono-methylether with chloro-acetonitrile, zinc chloride, a current of gaseous HCl and potassium acetate to yield 6-hydroxy-4-methoxy-coumaran-3-one (III), (c) redn. of (III) with hydrazine hydrate and KOH to yield 6-hydroxy-4-methoxy-coumarone (IV), (d) cyclisation of (IV) with acrylonitrile, zinc chloride and gaseous HCl to give 3,4,4',5'-tetrahydro-5-methoxypsoralene (V) and (e) dehydrogenation of (V) to give (I). Used in treatment of psoriasis and dermatoses such as vitiligo(leukoderma), a typical eczema and fungal mycosis. (I) is administered orally, in doses of 40-300 mmg(pref. 60-150 mmg), or topically using compsns. containing 100-1000 ppm of (I) and is activated by irradiation with ultraviolet. The activity of (I) (as measured by its phototoxicity) is only about 25% less than the activity of currently used 8-methoxy-psoralene whilst its acute toxicity is much less (17x) giving it a superior therapeutic index. Prepn. uses economic starting cpds. contains less stages than known processes, uses a readily available redn. catalyst which avoids ageing and regeneration problems and gives good yields.

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Cited By (4)

    Publication numberPublication dateAssigneeTitle
    DE-3023109-A1January 08, 1981Gerot PharmazeutikaMethoxsalenpraeparat zur oralen verabreichung
    EP-0586282-A1March 09, 1994Jean-Jacques GoupilCompositions to piques comprenant du 5-méthoxypsoralène
    FR-2524801-A1October 14, 1983Goupil Jean JacquesMedicaments contg. 5-methoxy psoralen - for oral and topical treatment of cancers
    FR-2695036-A1March 04, 1994Goupil Jean JacquesHuile contenant du 5-méthoxypsoralène à une concentration de 60 à 100 PPM et son utilisation pour le traitement du psoriasis.